Embolic protection device

Abstract

An embolic protection device is provided for deployment within a body vessel to collect embolic debris there from. The device includes a filter for collecting the embolic debris and a frame for supporting the filter. The frame generally defines a closed loop that has a collapsed state and an opened state. Furthermore, the frame includes a tube portion that receives an opening means to open the closed loop from the collapsed state to the opened state.

Claims

What is claimed is: 1. An embolic protection device for collecting embolic debris within a body vessel having an inner wall, the embolic protection device comprising: a tubular frame having a lumen and a longitudinal axis, wherein a portion of the frame forms an annular closed loop having a collapsed state and an opened state; a telescoping portion having an end and being slidably received within the lumen of the closed loop of the frame to open the closed loop from the collapsed state to the opened state; a connecting portion including a first portion radially connected to the tubular frame and a second portion extending from the first portion to connect to the closed loop, the second portion being disposed coaxially with the tubular frame, the first portion being radially off-set from the centerpoint; and a filter connected to the frame to collect the embolic debris, the filter having a proximally located mouth portion, the annular closed loop being positioned within the filter to open the mouth portion towards the inner wall of the body vessel; wherein a radius of the opened state closed loop is adjustable based on a force applied to the end the telescoping portion by a fluid within the lumen of the frame, the force moving the telescoping portion along the longitudinal axis of the tubular frame with the fluid flowing from the connecting portion to the tubular frame. 2. An embolic protection device as in claim 1 , wherein the closed loop includes a first radius measured perpendicularly to a longitudinal axis of the body vessel when the closed loop is in the collapsed state and having a second radius measured perpendicularly to the longitudinal axis when the closed loop is in the opened state, wherein the second radius is greater than the first radius. 3. An embolic protection device as in claim 1 , wherein the closed loop includes a circumferential outer surface engaging the body vessel in a fluid-tight connection when the closed loop is in the opened state. 4. An embolic protection device as in claim 1 , wherein the closed loop is torus-shaped when the closed loop is in the opened state. 5. An embolic protection device as in claim 1 , wherein the connecting portion is in fluid communication with and extending away from the closed loop. 6. An embolic protection device as in claim 5 , further comprising a guide wire slidably coupled with the connecting portion. 7. An embolic protection device as in claim 6 , further comprising a locator device having radiopaque properties that is coupled with the closed loop. 8. An embolic protection device as in claim 5 , further comprising a delivery device that receives the closed loop in the collapsed state. 9. An embolic protection device as in claim 1 , further comprising a second frame defining a second closed loop having a collapsed state and an opened state, wherein the second frame is located distally of the frame. 10. An embolic protection device for collecting embolic debris within a body vessel having an inner wall, the embolic protection device comprising: a tubular frame having a centerpoint, a lumen, and a longitudinal axis, wherein a portion of the frame forms an annular closed loop having a collapsed state and an opened state, the lumen configured to receive a fluid to inflate the closed loop into the opened state; a connecting portion including a first portion radially connected to the tubular frame and a second portion disposed coaxially with the tubular frame, the first portion being one of generally intersecting the centerpoint and radially off-set from the centerpoint; and a filter connected to the frame to collect the embolic debris, the filter having a proximally located mouth portion, the annular closed loop being positioned within the filter to open the mouth portion towards the inner wall of the body vessel; the frame including a telescoping portion having an end and being slidably received within the lumen of the closed loop such that a radius of the opened state closed loop is adjustable based on a force applied to the end the telescoping portion by the fluid that flows from the connecting portion to the tubular frame, the force moving the telescoping portion along the longitudinal axis of the tubular frame. 11. An embolic protection device as in claim 10 , wherein the tubular frame includes a tube portion, the tube portion of the frame defines a first internal volume when the closed loop is in the collapsed state, the tube portion of the frame defines a second internal volume when the closed loop is in the opened state, and the second internal volume is greater than the first internal volume. 12. An embolic protection device as in claim 10 , wherein the tube portion is composed of an elastic material. 13. An embolic protection device as in claim 10 , wherein the connecting portion is in fluid communication with and extends away from the closed loop, wherein the tube portion defines a continuous flow path around the closed loop and wherein the flow path is in fluid communication with the connecting portion. 14. An embolic protection device as in claim 10 , further comprising a second frame defining a second closed loop having a collapsed state and an opened state, wherein the second frame is located distally of the frame, and wherein the filter is connected to the frame and the second frame. 15. An embolic protection device for collecting embolic debris within a body vessel, the embolic protection device comprising: a tubular frame having a lumen and a longitudinal axis, wherein a portion of the frame forms an annular closed loop having a collapsed state and an opened state, the lumen of the frame configured to receive a fluid; a connecting portion including a first portion radially connected to the tubular frame and a second portion disposed coaxially with the tubular frame, the first portion being one of generally intersecting the centerpoint and radially off-set from the centerpoint; and an opening member having an end and being received by the lumen of the closed loop of the frame to open the closed loop into the opened state based on a force applied to the end of the opening member by the fluid that flows from the connecting portion to the tubular frame, the force moving the opening member along the longitudinal axis of the tubular frame; and a filter coupled with the closed loop to collect the embolic debris, the filter having a proximally located mouth portion, the annular closed loop being positioned within the filter to open the mouth portion towards the inner wall of the body vessel. 16. An embolic protection device as in claim 15 , wherein the opening member includes a wire. 17. An embolic protection device as in claim 1 , wherein the telescoping portion forms a fluid-tight seal with an inner surface of the tubular frame. 18. An embolic protection device as in claim 1 , further comprising a hard stop mechanism that prevents the telescoping portion from exiting the receiving portion. 19. An embolic protection device as in claim 10 , wherein the telescoping portion forms a fluid-tight seal with an inner surface of the tubular frame. 20. An embolic protection device as in claim 15 , wherein the opening member forms a fluid-tight seal with an inner surface of the tubular frame. 21. The device of claim 10 wherein the second portion extends radially from the first portion when the first portion generally intersects the centerpoint.
CROSS-REFERENCE TO RELATED APPLICATION This application claims benefit of U.S. Provisional Application No. 60/661,731, filed Mar. 15, 2005 entitled Embolic Protection Device. BACKGROUND 1. Field of the Invention The invention relates generally to medical devices. More specifically, the invention relates to intravascular distal embolic protection devices. 2. Related Technology Embolic protection devices are percutaneously placed in a body vessel to prevent emboli from traveling and creating an undesirable embolism, e.g., pulmonary embolism. For example, vena cava filters are used for trapping emboli in the vena cava filter to prevent pulmonary embolism. Also, anti-platelet agents and anticoagulants may be used to breakdown blood clots. Moreover, snares and baskets (e.g., stone retrieval baskets) are used for retrieving urinary calculi. Additionally, occlusion coils are commonly used to occlude aneurysms and accumulate thrombi in a body vessel. Treatments for a stenotic lesion provide a potential in releasing blood clots and other thrombi plaque in the vasculature of the patient. One example is the treatment for a carotid artery stenosis. Generally, carotid artery stenosis is the narrowing of the carotid arteries, the main arteries in the neck that supply blood to the brain. Carotid artery stenosis (also called carotid artery disease) is a relatively high risk factor for ischemic stroke. The narrowing is usually caused by plaque build-up in the carotid artery. Carotid angioplasty is a more recently developed treatment for carotid artery stenosis. This treatment uses balloons and/or stents to open a narrowed artery. Carotid angioplasty is a procedure that can be performed via a standard percutaneous transfemoral approach with the patient anesthetized using light intravenous sedation. At the stenosis area, an angioplasty balloon is delivered to predilate the stenosis in preparation for stent placement. The balloon is then removed and exchanged via catheter for a stent delivery device. Once in position, a stent is deployed across the stenotic area. If needed, an additional balloon can be placed inside the deployed stent for post-dilation to make sure the struts of the stent are pressed firmly against the inner surface of the vessel wall. During the stenosis procedure however, there is a risk of such blood clots and thrombi being undesirably released into the blood flow within the vasculature. Therefore, distal embolic protection devices, such as occlusive devices and filters, have been developed to trap and to prevent the downstream travel of the blood clots and thrombi. The filters are typically advanced downstream of a site that is to be treated and then opened into an opened state to increase the filter area. The blood clots and thrombi can be captured in the opened filter while blood is still able to flow therethrough. However, filter devices may fail to completely open within the blood vessel, leaving gaps between the filter outer surface and the blood vessel inner surface. These gaps may permit the above-described blood clots and thrombi to flow past the filter, unoccluded. As a result, the unoccluded blood clots and thrombi may thereby compromise the blood flow at a location distal from the treatment site. Thus, there is a need to improve the opening of the filter device within the blood vessel to effectively capture the unoccluded blood clots and thrombi. SUMMARY In one aspect of the present invention, an embolic protection device is provided to collect embolic debris from within a body vessel. Generally, the device includes a filter for collecting embolic debris and a frame for supporting the filter. The frame generally defines a closed loop that has a collapsed state and an opened state. Furthermore, the frame includes a tube portion that receives an opening means to open the closed loop from the collapsed state to the opened state. In another aspect of the present invention, the closed loop includes a circumferential outer surface that engages the body vessel in a substantially fluid-tight connection when the closed loop is in the opened state. The outer surface defines a substantially circular shape when the closed loop is in the opened state. Generally, the closed loop is substantially torus-shaped in the opened state. In yet another aspect of the present invention, the device further includes a connecting portion that is in fluid communication with the closed loop. More specifically, the connecting portion is connected to the closed loop and extends away therefrom in a direction that is substantially parallel with a longitudinal axis of the body vessel. The connecting portion may also extend radially away from the closed loop. In another aspect of the present invention, the device further includes a guide wire that extends along the body vessel longitudinal axis. The guide wire is slidably coupled with the connecting portion such as to permit the device to travel along the longitudinal axis to its desired location within the body vessel. In yet another aspect of the present invention, the embolic protection device includes a locator device having radiopaque properties. The radiopaque properties of the locator device permit a device user, such as a medical professional, to locate the embolic protection device within a patient's body. Furthermore, the embolic protection device is preferably delivered into the body vessel via a delivery device that receives the closed loop in the collapsed state. More preferably, the delivery device is a catheter. The present invention may also include a second frame that defines a second closed loop that supports the filter and that is positioned distally of the above-described frame. The second closed loop has a collapsed state and an opened state. More specifically, the second closed loop includes a tube portion for receiving an opening means and for opening the closed loop into the opened state, similarly to the above-described closed loop. In one aspect of the present invention, the opening means for opening the frame is a fluid that is injected into the tube portion to inflate the closed loop into the opened state. Preferably, the fluid is a saline solution that is injected through the connecting portion and into the frame. The tube portion may each have expandable internal volumes that increase when the fluid is injected therein. Furthermore, the tube portion may be composed of a generally elastic material to further permit the expansion. The fluid may also be used in the above-described design having first and second frames. In another aspect of the present invention, the opening means for opening the first and second frames is an opening member received by the tube portion to open the closed loop into the opened state. Preferably, the opening member is a wire having an axial stiffness that is substantially greater than its radial stiffness. The stiffness coefficients of the wire permit navigation of the wire through the body vessels. The wire may be a hollow tube to improve the ratio of stiffness coefficients and to minimize part weight. Additionally, in the above-described design having first and second frames, the embolic protection device may include a second opening member that is received by the second frame. In yet another aspect of the present invention, the frame includes a telescoping portion that is received within a receiving portion of the frame. The telescoping portion is slideable within the receiving portion such as to adjust a radius of the opened state closed loop. More specifically, as the fluid fills the tube portion of the frame and applies a force onto the telescoping portion the frame radially opens towards the blood vessel walls. Further objects, features and advantages of this invention will become readily apparent to persons skilled in the art after a review of the following description, with reference to the drawings and claims that are appended to and form a part of this specification. BRIEF DESCRIPTION OF THE DRAWINGS FIG. 1 is an environmental side view of an embolic protection device having a frame and a filter opened into opened states and embodying the principles of the present invention, where the embolic protection device is shown located within a partially cut-away blood vessel; FIG. 2 is a cross-sectional view taken along line 2 - 2 in FIG. 1 showing the embolic protection device opened into the opened state by a fluid located within a tube portion of the frame; FIG. 3 is a cross-sectional view taken along line 3 - 3 in FIG. 2 , showing the fluid located within the tube portion of the frame; FIG. 4 is a cross-sectional view taken along line 4 - 4 in FIG. 2 , showing a telescoping portion of the frame being received within a receiving portion of the frame; FIG. 5 is a plan view of the embolic protection device positioned within a delivery device, where the frame is deflated into a collapsed state from the substantial removal of the fluid from the tube portion; FIG. 6 shows a plan view of the embolic protection device deployed from the delivery device, where the frame is deflated into the collapsed state; FIG. 7 is a cross-sectional view taken along line 7 - 7 in FIG. 6 showing the embolic protection device deflated into the collapsed state; FIG. 8 is a cross-sectional view taken along line 8 - 8 in FIG. 6 showing the tube portion of the frame having a decreased internal volume from the substantial removal of the fluid from the tube portion; FIG. 9 is a cross-sectional view, similar to that shown in FIG. 2 , of an alternative design embodying the principles of the present invention, including a wire received within the tube portion to open the frame into the opened state; FIG. 10 is an enlarged cross-sectional view taken along line 10 - 10 in FIG. 9 , showing the wire received within the tube portion of the frame; FIG. 11 is an enlarged cross-sectional view similar to that shown in FIG. 9 , showing a hollow wire received within the tube portion of the frame; FIG. 12 is a plan view of an embolic protection device, similar to that shown in FIG. 1 , of an alternative design embodying the principles of the present invention, including first and second frames opened into an opened state to open the filter; FIG. 13 is a cross-sectional view taken along line 13 - 13 in FIG. 12 showing the embolic protection device opened into the opened state by the fluid located within the tube portions of the first and second frames; and FIG. 14 is an enlarged cross-sectional view similar to that shown in FIG. 13 , showing a hollow wire received within the tube portions of the first and second frames. DETAILED DESCRIPTION Embodiments of the present invention generally provide distal protection devices, distal protection apparatus, and methods for capturing emboli in a body vessel during angioplasty for treatment of a stenosis. One particular stenosis is a carotid artery stenosis. The embodiments solve the concerns of current stenosis treatments, such as the relatively high risks of surgery and the potential release of emboli into the vasculature during the stenosis procedure. Embodiments of the present invention provide a relatively low risk approach to capturing emboli released during a stenosis procedure, e.g., balloon angioplasty. Referring now to the drawings, FIG. 1 shows an embolic protection device 10 positioned within a body vessel, such as a blood vessel 12 that has a blood flow therethrough in a direction generally indicated by reference numeral 14 . The embolic device 10 includes a filter 16 and is positioned downstream of emboli 18 , such as blood clots and plaque fragments, to trap and to prevent the downstream travel of the emboli 18 , thereby reducing the likelihood of an embolism or of the downstream blood vessels becoming blocked. As will be discussed in more detail below, the filter 16 operates similarly to a sieve, having openings 20 that permit blood to flow therethrough while preventing the emboli 18 from doing the same. The filter 16 is composed of a mesh or a web-like material 22 , but any suitable material may be used. More specifically, the filter material 22 is preferably strong enough to avoid rupture during use and thin enough to conveniently fit within the blood vessel 12 . Furthermore, the filter material 22 is preferably sufficiently flexible such that the filter 16 is able to conform to various shapes and configurations, as may be needed to properly engage the blood vessel 12 . The filter 16 includes a proximally-located mouth portion 24 that is substantially opened to an opened state 26 for receiving the emboli 18 . Preferably, the embolic device 10 forms a substantially fluid-tight seal 30 with the blood vessel when the mouth portion 24 is in the opened state 26 . The seal 30 may be formed by the mouth portion, the filter 16 , or both. The seal 30 prevents emboli 18 from flowing around the filter 16 and from potentially causing the above-described conditions. The filter 16 further includes a tail portion 29 located distally of the mouth portion 24 . The tail portion 29 is substantially closed, such as to permit blood to flow through the openings 20 , while simultaneously preventing emboli 18 from doing the same. Therefore, the emboli 18 are collected within the tail portion 29 . The mouth portion 24 is held in the opened state 26 by a frame 32 that extends around the perimeter of the mouth portion 26 . The frame 32 is collapsible into a collapsed state 33 , as shown in FIGS. 5 and 6 , such as to permit blood flow 14 between the frame 32 and the blood vessel inner walls 36 . As will be discussed in more detail below, the frame 32 is typically in the collapsed state 33 while delivering the device 10 into a desired location of the blood vessel 12 and while removing the device 10 from the desired location. The frame 32 is preferably composed of a flexible material such as plastic or of a compliant material such as rubber. Alternatively, the frame 32 is composed of a plurality of generally rigid sections that are movable with respect to each other. Additionally, any sufficient collapsible design that permits delivery of the device 10 into the blood vessel 12 may be used. The frame 32 forms an annular closed loop 34 that is positioned within the filter 16 to open the mouth portion 24 towards an inner wall 36 of the blood vessel 12 . Alternatively, the filter 16 may be connected to the radially inner surface of the closed loop 34 . A first portion 38 of the frame 32 is connected to a second portion 40 of the frame such that the closed loop 34 defines a continuous path 37 . The closed loop 34 shown in FIG. 2 is generally circular, but any suitable shape and size may be used. The first and second portions 38 , 40 are connected by any suitable means, such as by welding, adhesives, bonding (such as through heat treatment), or mechanical fasteners. Alternatively, the frame 32 is a single, unitary component. The closed loop 34 design improves the seal 30 between the frame 32 and the blood vessel 12 . More specifically, a free, unconnected portion of the frame would be able to freely flow downstream rather than tightly engaging the blood vessel 12 . The closed loop 34 includes an outer circumferential surface 42 that forms the substantially fluid-tight seal 30 with the blood vessel 12 when the frame 32 is in the opened state 26 . The inner walls 36 of blood vessels 12 typically have a generally circular cross-section. Therefore, to effectively form the substantially fluid-tight seal 30 , the outer surface 42 of the closed loop 34 also has a generally circular shape when the frame 32 is in the opened state 26 . Furthermore, the closed loop 34 includes an inner circumferential surface 44 corresponding to the shape of the outer circumferential surface 42 such that the opened state 26 closed loop 34 is substantially torus-shaped. The closed loop 34 is able to open to the opened state 26 by receiving an opening means. More specifically, the closed loop 34 is defined by a tube 46 having a tube portion 48 that defines an internal volume 49 and that is able to receive the opening means. The opening means may be any fluid or solid component that is suitable for opening the closed loop 34 in the radial direction 28 . Acceptable fluids include, but are not limited to, saline and water, and acceptable solids include, but are not limited to, a wire and a tube. In one design, shown in FIGS. 2 and 3 , the opening means is a fluid 50 located within the tube portion 48 that causes the closed loop 34 to open in the radial direction 28 . More specifically, as the tube portion 48 of the closed loop 34 fills with the fluid 50 , the circumferential length of the closed loop 34 along the path 37 is maximized, thereby causing the radius 52 of the closed loop 34 to increase. The fluid 50 shown in the Figures is a saline solution, but any suitable fluid may be used. The medical professional using the embolic protection device 10 is able to position the closed loop 34 by controlling the radius 52 of the closed loop 34 via a connecting portion 66 extending away from the closed loop 34 . More specifically, the connecting portion 66 shown in FIGS. 1-4 includes a lumen 68 that receives the fluid 50 and that is in fluid communication with the closed loop 34 tube portion 48 . Therefore, the medical professional is able to inject the fluid into the closed loop 34 via the connecting portion 66 . The connecting portion 66 shown in the Figures includes a first portion generally intersecting a centerpoint 69 of the frame 32 and a second portion extending radially from the first portion to connect to the closed loop 34 . Alternatively, the connecting portion 66 may be radially off-set from the centerpoint 69 . In another design, the frame 32 includes a valve (not shown) to force the connecting portion 66 to inflate or open. The connecting portion 66 and the frame 32 preferably each have shape memory such as to naturally conform to a desired position when in the opened state 26 . More specifically, the connecting portion 66 and frame 32 are preferably positioned substantially perpendicular to each other such that a plane defined by the frame 32 is normal to the connecting portion 66 or are connected by a curved portion that generally connects two perpendicular portions. This configuration improves the seal 30 between the frame 32 and the blood vessel 12 because it urges the frame 32 to lie along a plane that is perpendicular to a longitudinal axis 53 of the blood vessel 12 . Stated another way, the plane of the closed loop is preferably non-parallel to the longitudinal axis 53 of the blood vessel 12 and is most preferably perpendicular to the longitudinal axis 53 . Blood vessels 12 typically vary significantly in size and in shape. Therefore the radius 52 of the opened state 26 frame is preferably variable to effectively form the seal 30 . More specifically, the frame 32 preferably includes a mechanism that permits the variation of the opened state radius 52 . Referring to FIG. 4 , one such mechanism is a telescoping portion 54 slidably received within the tube 46 to permit variation of the opened state radius 52 . The telescoping portion 54 forms a generally fluid-tight seal 56 with the inner surface of the tube 46 to prevent the fluid 50 from flowing between the respective components 54 , 46 . As a result, when the tube 46 becomes filled with fluid, a force 58 is applied onto he telescoping portion 54 . The force 58 causes the telescoping portion 54 to move along the path 37 , thereby increasing the circumferential length and the opened state radius 52 of the frame 32 . The telescoping portion 54 and/or the tube 46 may include a hard stop mechanism (not shown) that prevents the circumferential length from expanding beyond a particular size. More specifically, the hard stop mechanism prevents the telescoping portion 54 from exiting the tube 46 . During operation of the embolic protection device 10 , the telescoping portion 54 will stop moving when the force 58 from the fluid flow is generally equal to a force between the expanding tube 46 and the blood vessel inner wall 36 . Furthermore, the telescoping portion 54 will also stop moving when the hard stop is engaged. The hand stop is preferably positioned so that the closed loop 34 is able to expand to form the seal 30 before the hand stop is engaged. Referring back to FIG. 3 , another mechanism for varying the opened state 26 closed loop radius 52 is a variable internal diameter 60 of the tube 46 . For example, as shown in FIG. 3 , the tube may be composed of an elastic material 62 such that the internal diameter 60 of the tube 46 is expandable. Therefore, when an increased volume of the fluid 50 is inserted within the tube 46 , the internal diameter 60 and an external diameter 64 of the tube 46 increase and cause the opened state 26 closed loop radius 52 to increase. The closed loop 34 in this design may define a continuous fluid flow path along the path 37 such that the first portion 38 and the second portion 40 are in fluid connection with each other. The medical professional using the embolic protection device 10 is also able to control the position of the embolic protection device 10 via a guide wire 70 and a connecting sleeve 72 . More specifically, the connecting portion 66 is connected to the connecting sleeve 72 , which slidably receives the guide wire 70 . Therefore, the embolic protection device 10 is able to travel through the blood vessels in a direction generally parallel to the guide wire 70 . The guide wire 70 intersects the filter 16 adjacent to the tail portion 29 thereof, which preferably includes a sealing component 74 to permit sliding movement between the filter 16 and the guide wire 70 while preventing emboli 18 from flowing therebetween. The connecting sleeve 72 also preferably includes a locator device having radiopaque properties to permit the medical professional to more effectively track the location of the device 10 within the blood vessels 12 . More specifically, the connecting sleeve 72 includes a coating of radiopaque material 76 that is visible through the patient's body with the assistance of detection equipment. The locator device is particularly beneficial during the delivery of the embolic protection device 10 into the desired location of the blood vessel 12 and during the removal of the device 10 from the same. Referring now to FIGS. 1-3 and 6 - 8 , the details of the opened state 26 and the collapsed state 33 will now be discussed in more detail. Preferably, the closed loop 34 has the opened state radius 52 ( FIG. 2 ) when in the opened state 26 and a closed state radius 80 ( FIG. 7 ) when in the collapsed state 33 . As discussed above, the opened state radius 52 is substantially equal to that of the blood vessel 12 , while the closed state radius 80 is substantially smaller than that of the blood vessel 12 . Therefore, when the frame 32 is in the collapsed state 33 a gap 82 is present between the frame 32 and the blood vessel 12 , permitting the embolic protection device 10 to travel through the blood vessel 12 as desired. As also discussed above, the collapsed state 33 is particularly desirable during the delivery the embolic protection device 10 into the desired location of the blood vessel 12 and during the removal of the device 10 from the same. Furthermore, if the frame 32 is made of an elastic material, the internal volume of the closed loop may also vary as the opening means is inserted into the tube portion 48 . The tube portion 48 defines the first internal volume 49 ( FIG. 3 ) when the frame 32 is in the opened state 26 and a second internal volume 84 ( FIG. 8 ) when in the collapsed state 33 . The first internal volume 49 is preferably substantially greater than the second internal volume 84 due to the fluid 50 located within the tube portion 48 during the opened state 26 . More specifically, the varying internal volume may occur for one or both of the following reasons. First, the fluid 50 is preferably removed from within the tube portion 48 when the frame is in the collapsed state 33 , thereby creating a partial vacuum and a reduced volume within the tube portion 48 during this state 33 . Secondly, the fluid 50 preferably causes expansion of the compliant walls of the tube 26 during the opened state 26 , thereby increasing the first internal volume 49 . When the frame 32 is in the collapsed state 33 , all or a substantial portion of the air is also removed from the tube portion 48 so that the tube portion 48 can be more easily filled and also to minimize or prevent air from entering the blood vessel 12 in the case of a ruptured tube portion 48 . Referring now to FIGS. 5 and 6 , the procedure for deployment of the embolic protection device 10 will now be discussed in more detail. The embolic protection device 10 preferably includes a delivery device, such as a catheter 86 , for positioning the embolic protection device 10 within the blood vessel 12 at the desired location. More specifically, as shown in FIG. 5 , the catheter 86 is inserted into the blood vessel 12 at a location downstream of the emboli 18 while the embolic protection device 10 is located within the catheter 86 in the collapsed state 33 . Then, as shown in FIG. 6 , the embolic protection device 10 remains in the collapsed state 33 and is released from the catheter 86 and is permitted to flow along the blood stream to its desired location. Next, the catheter 86 is removed from the blood vessel 12 and the embolic protection device 10 is opened into the opened state 26 by the medical professional. Alternatively, the catheter 86 remains within the blood vessel 12 after the deployment of the embolic protection device 10 , as is the case with many catheters that are configured to deploy balloon catheter along with the embolic protection device 10 . In another design, shown in FIGS. 9-11 , the opening means is an opening member, such as a wire 88 , located within the tube portion 48 that causes the closed loop 34 to open in the radial direction 28 . More specifically, the wire 88 is fed into the tube portion 48 to cause the closed loop 34 to open in the radial direction 28 . The wire 88 preferably has an axial stiffness in the axial direction 90 that is greater than its radial stiffness in the radial direction 92 to permit the wire 88 to negotiate the bending path through the tube 46 . Furthermore, as shown in FIG. 11 , the opening member may be a hollow tube 94 to decrease the radial stiffness in the radial direction 92 ′ and to reduce component weight and cost. In this embodiment, the tube portion 48 of the connecting portion 66 also preferably receives the wire 88 . Furthermore, the connecting portion 66 and the closed loop 34 are connected to each other such that the medical professional can easily feed the wire 88 through the connecting portion 66 and into the closed loop 34 . Additionally, this embodiment may include a mechanism that permits the variation of the opened state radius 52 . More specifically, the device 10 may include the telescoping portion 54 slidably received within the tube 46 to permit variation of the opened state radius 52 . However, instead of being moved forward by a fluid force, the telescoping portion 54 in this embodiment is driven forward by the wire 88 . Alternatively, the device 10 may include the tube 46 having a flexible internal diameter 60 . However, instead of being radially opened by fluid pressure, the internal diameter 60 is increased by the wire 88 having a larger diameter than the tube 46 . Referring now to FIGS. 12-14 , another embodiment of the present invention will now be discussed. More specifically, the embolic protection device 10 in FIG. 12 includes a second frame 96 defining a second closed loop 97 having a collapsed state (not shown) and an opened state 99 similar to the frame 32 described above. Furthermore, the second frame 96 is connected to a second connecting portion 98 . The first and second frames 32 , 96 of the embolic protection device 10 shown in FIGS. 12 and 13 are opened into the respective opened states 26 , 99 by the fluid 50 located within the tube portions of the tubes 46 . In this design, the respective connecting portions 66 , 98 of the respective frames 32 , 96 are both in fluid communication with each other such that the medical professional can control the inflation of both frames 32 , 96 simultaneously. Alternatively, other suitable designs may be used. The first and second frames 32 , 96 of the embolic protection device 10 shown in FIG. 14 are opened into the respective opened states 26 , 99 by the wires 88 a , 88 b located within the tube portions of the tubes 46 . In this design, the respective connecting portions 66 , 98 of the respective frames 32 , 96 are not internally connected with each other so the two wires 88 a , 88 b can be used to independently control the inflation of both frames 32 , 96 . Alternatively, other suitable designs may be used. It is therefore intended that the foregoing detailed description be regarded as illustrative rather than limiting, and that it be understood that it is the following claims, including all equivalents, that are intended to define the spirit and scope of this invention.

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