Substd. pyr(im)idones - with darkness-adaptation accelerating properties

Omega-substituierte alkane

Abstract

Stright- or branched-chain 4-18C alkanes substd. in the omega-position by a heterocyclic residue of formula (Ia) or (Ib) are new cmpds. (where X is CH or N and Y is O or S). The new compounds have the property of accelerating dark-adaptation. This is demonstrated by results of electroretinographic studies of mice given in the specification. EXAMPLE 1-Bromohexane (17g) and 2-pyridone potassium salt (13g) are stirred 2 hrs. in refluxing EtOH, then KBr is filtered off and the filtrate concentrated in vacuo. The residue is fractionated under water-aspirator vacuum to give 1-n-hexyl-2-pyridone distilling at ca. 160 degrees C.

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Cited By (4)

    Publication numberPublication dateAssigneeTitle
    EP-0277270-A2August 10, 1988MEDICE Chem.-Pharm. Fabrik Pütter GmbH & Co. KGN-alkylated quaternary nitrogen-containing heterocycles, process for their preparation and their use in pharmaceutical compositions
    EP-0277270-A3April 10, 1991MEDICE Chem.-Pharm. Fabrik Pütter GmbH & Co. KGN-alkylated quaternary nitrogen-containing heterocycles, process for their preparation and their use in pharmaceutical compositions
    EP-0513878-A2November 19, 1992MEDICE Chem.-Pharm. Fabrik Pütter GmbH & Co. KGPharmaceutical compositions containing cationic surfactants
    EP-0513878-A3October 13, 1993Medice Chem.-Pharm. Fabrik Puetter Gmbh & Co. KgPharmaceutical compositions containing cationic surfactants